科技奖项
l 2022年国家教育部科技进步奖 一等奖
项目名称：强直性脊柱炎免疫致病机理的研究和临床转化
l 2019年上海科技进步奖 一等奖
项目名称：强直性脊柱炎和类风湿关节炎致病机理和诊疗策略的关键技术研究
l 2013年上海医学科技奖 一等奖
项目名称：强直性脊柱炎免疫遗传发病机制及控制策略研究
人才计划
l 中组部高层次人才计划“国家特聘专家”
l 上海市领军人才
l 上海市优秀学科带头人
l 上海市浦江风湿青年医师计划
人才培养
姓 名 | 毕业时间 | 学 位 | 现任职 |
刘 彧 | 2003 | 博 士 | 上海交通大学医学院附属同仁医院风湿免疫科，主任 |
吴 歆 | 2005 | 硕 士 | 海军军医大学第二附属医院（长征医院）风湿免疫科，副主任 |
包 军 | 2006 | 博 士 | 上海交通大学医学院附属新华医院小儿呼吸科，副主任 |
戴生明 | 2006 | 博 士 | 上海市交通大学医学院第六附属医院风湿免疫科，主任 |
刘 欢 | 2006 | 硕 士 | 上海市长宁区光华中西医结合医院特需科，主治医师 |
孔晓东 | 2006 | 硕 士 | 上海冬雷脑科医院神经内科，主任 |
程 昉 | 2007 | 博 士 | 上海交通大学医学院附属第九人民医院风湿免疫科，副主任 |
严定安 | 2007 | 硕 士 | 广西桂平91241部队，主治医师 |
夏正坤 | 2007 | 博 士 | 南京大学附属金陵医院儿童肾脏诊疗中心，主任 |
张璐定 | 2008 | 博 士 | 海军军医大学第二附属医院（长征医院）医院门诊部，主任 |
吴 歆 | 2008 | 博 士 | 海军军医大学第二附属医院（长征医院）风湿免疫科，副主任 |
王忠伟 | 2008 | 硕 士 | 博鳌国际医院，副总裁 |
魏 萌 | 2009 | 博 士 | 成都军区总医院肾内科，副主任 |
林翊萍 | 2009 | 博 士 | 北部战区总医院中医风湿免疫科，主任 |
蔡 青 | 2009 | 博 士 | 海军军医大学第一附属医院（长海医院）风湿免疫科，主任医师 |
殷 健 | 2010 | 硕 士 | 海军军医大学第二附属医院（长征医院）风湿免疫科，副主任医师 |
赵 静 | 2011 | 硕 士 | 澳大利亚昆士兰大学脑研究所，博士后 |
谢伟林 | 2012 | 博 士 | 山东省烟台毓璜顶医院风湿免疫科，主任 |
黄少兰 | 2012 | 硕 士 | 上海赛诺菲制药有限公司，医学联络官 |
郭 倩 | 2012 | 硕 士 | 嘉和生物药业有限公司，医学副总监 |
刘 玮 | 2013 | 博 士 | 中国人民解放军联合勤务保障部队第900医院呼吸内科，副主任医师 |
叶玲英 | 2013 | 博 士 | 海军军医大学第二附属医院（长征医院）风湿免疫科，副主任医师 |
高 洁 | 2013 | 硕 士 | 盐城市第一人民医院肿瘤科，主治医师 |
姜 磊 | 2014 | 博 士 | 海军军医大学第二附属医院（长征医院）风湿免疫科，副主任医师 |
殷 健 | 2014 | 博 士 | 海军军医大学第二附属医院（长征医院）风湿免疫科，副主任医师 |
吕 颖 | 2014 | 硕 士 | 郑州大学第一附属医院放疗科，主治医师 |
王艺文 | 2014 | 硕 士 | 嘉兴市第一医院风湿免疫科，主治医师 |
金艳华 | 2015 | 博 士 | 北部战区总医院肾内科，副主任医师 |
周 凌 | 2016 | 博 士 | 海军军医大学第二附属医院（长征医院）风湿免疫科，副主任医师 |
陈 凌 | 2016 | 硕 士 | 海军军医大学第二附属医院（长征医院）风湿免疫科，主治医师 |
林 丽 | 2016 | 硕 士 | 海军军医大学第二附属医院（长征医院）风湿免疫科，主治医师 |
唐仕超 | 2016 | 硕 士 | 上海交通大学医学院附属同仁医院风湿免疫科，主治医师 |
王 赓 | 2016 | 硕 士 | 澳大利亚昆士兰大学，博士生 |
张 倜 | 2017 | 博 士 | 东部战区总医院肾内科，主治医师 |
刘 欣 | 2017 | 博 士 | 海军军医大学第二附属医院（长征医院）风湿免疫科，主治医师 |
汤予双 | 2017 | 博 士 | 东部战区总医院福州分院内分泌科，主任 |
李 婷 | 2017 | 博 士 | 海军军医大学第二附属医院（长征医院）风湿免疫科，副主任医师 |
吴慧珍 | 2017 | 硕 士 | 上海市新华医院全科，主治医师 |
卞建叶 | 2018 | 硕 士 | 上海交通大学医学院附属同仁医院重症医学科，住院医师 |
金茜玫 | 2019 | 博 士 | 海军军医大学第二附属医院（长征医院）风湿免疫科，主治医师 |
张志国 | 2019 | 博 士 | 百时美施贵宝研发部，临床研究医生 |
朱长浩 | 2019 | 博 士 | 海军特色医学中心肾内科，主治医师 |
钟驾云 | 2019 | 硕 士 | 中国人民解放军31627部队，主治医师 |
康子健 | 2019 | 硕 士 | 海军军医大学第二附属医院（长征医院）风湿免疫科，博士生 |
霍永宝 | 2020 | 博 士 | 广州医科大学第二附属医院风湿科，主治医师 |
刘亚群 | 2020 | 博 士 | 海军青岛特勤疗养中心骨关节康复科，主治医师 |
高丽红 | 2020 | 硕 士 | 北部战区海军航空兵保障部门诊部，住院医师 |
耿旭强 | 2020 | 硕 士 | 海军军医大学第二附属医院（长征医院）风湿免疫科，博士生 |
汪苑琼 | 2021 | 硕 士 | 南部战区海军第一医院，主治医师 |
康子健 | 2022 | 博 士 | 上海市第六人民医院风湿免疫科，住院医师 |
叶倩仪 | 2022 | 硕 士 | 海军军医大学第二附属医院（长征医院）风湿免疫科，住院医师 |
田浩然 | 2022 | 硕 士 | 中国人民解放军73096部队，主治医师 |
牟 兴 | 2023 | 硕 士 | 中国人民解放军32359部队，住院医师 |
蔡 月 | 2023 | 硕 士 | 盐城市第一人民医院，住院医师 |
王 涛 | 2024 | 硕 士 | 北戴河康复疗养中心，主治医师 |
王秀雯 | 2024 | 博 士 | 海军军医大学第二附属医院（长征医院）风湿免疫科，主治医师 |
耿旭强 | 2024 | 博 士 | 海军军医大学第二附属医院（长征医院）风湿免疫科，主治医师 |
基金项目
1. 强直性脊柱炎发生机制及控制策略研究，国家科技部“973计划”项目，2014年，2800万元
2. 发育中胸腺上皮细胞和胸腺细胞间的相互作用Ⅱ，国家科技部“973计划”项目，2010年，283万元
3. 疟原虫感染的免疫应答及调控机制，国家科技部“973计划” 项目，2007年，395万元
4. 新型抗体药物在自身免疫性疾病临床治疗和研究中的应用，科技部国家高技术研究发展计划（863计划），2007年，200万元
5. 抗体分子的智能设计筛选技术平台与示范应用，国家重点研发计划（重点专项），2022年，150万元
6. 强直性脊柱炎免疫遗传学机制及其临床转化研究，国家自然科学基金委（国际(地区)合作与交流项目），2023年，210万元
7. 遗传变异介导的免疫失衡在强直性脊柱炎发病机制中的作用，国家自然科学基金委（重点项目），2014年，320万元
8. STAT3基因的遗传变异、TH17淋巴细胞与强直性脊柱炎相关性研究，国家自然科学基金委（重大国际合作研究项目），2011年，200万元
9. Sio-Australian neurogenetics initiative，澳大利亚国家研究委员会，2012年，70万元
10. IL23R and Ankylosing Spondylitis，澳大利亚国家健康和医学研究委员会，2009年，53万元
11. MHC Genetics of Ankylosing Spondylitis，澳大利亚国家健康和医学研究委员会，2009年，55万元
12. Malaria and vaccine research，澳大利亚国家健康和医学研究委员会，2013年，45万元
13. CD44可变剪切在基于IFN通路的干燥综合征分子分型中的作用及机制研究，国家自然科学基金委（面上项目），2022年，52万元
14. 基于AI的脊柱关节病早期诊断及疗效评估体系的建立，国家自然科学基金委（面上项目），2022年，52万元
15. 转录因子FOSB调控中性粒细胞I型干扰素通路参与狼疮肾炎发病的作用机制研究，国家自然科学基金委（青年项目），2022年，30万元
16. IL-4/Ikaros/Nr4a1调控自身反应性无能B细胞激活后凋亡在系统性红斑狼疮发病机制中的研究，国家自然科学基金委（面上项目），2020年，53万元
17. 单细胞测序技术解析肠道免疫细胞参与强直性脊柱炎关节炎症的机制研究，国家自然科学基金委（面上项目），2020年，55万元
18. Treg表位肽与细菌鞭毛蛋白偶联增强关节炎模型鼠的治疗效果，国家自然科学基金委（面上项目），2018年，60万元
19. LncRNA H19通过海绵吸附miR-130调控FGF-8/BMP-2在类风湿关节炎成纤维样滑膜细胞中的机制研究，国家自然科学基金委（青年项目），2018年，21万元
20. 强直性脊柱炎不同临床表型的遗传基因差异研究，国家自然科学基金委（面上项目），2017年，60万元
21. 褪黑素调控Th17细胞在强直性脊柱炎发病机制中的作用研究，国家自然科学基金委（青年项目），2016年，18万元
22. IL-7诱导CD4+记忆性T细胞生成的信号通路及其在胶原诱导性小鼠关节炎中的作用机制研究，国家自然科学基金委（青年项目），2015年，17万元
23. PTPN22基因变异及其调控信号通路在中国汉族人类风湿关节炎患者中的研究，国家自然科学基金委（青年项目），2014年，25万元
24. 不稳定Foxp3+T细胞在类风湿性关节炎中的作用，国家自然科学基金委（青年项目），2014年，23万元
25. 无能B细胞免疫耐受失衡参与系统性红斑狼疮发病机制的研究，国家自然科学基金委（青年项目），2013年，23万元
26. 中国汉族人群IL-23R的罕见遗传变异介导强直性脊柱炎发病机制的研究，国家自然科学基金委（面上项目），2013年，16万元
27. 强直性脊柱炎易感基因ERAP1的精细作图及致病机制的研究，国家自然科学基金委（面上项目），2013年，70万元
28. 强直性脊柱炎和类风湿关节炎诊疗的临床特征与其易感基因多态性的关联性研究，国家自然科学基金委（面上项目），2012年，80万元
29. 强直性脊柱炎Stat3的遗传变异对Th17细胞 生物学功能的影响，国家自然科学基金委（青年项目），2009年，18万元
30. 汉族人群类风湿性关节炎易感基因的研究，国家自然科学基金委（面上项目），2008年，33万元
31. 细胞免疫学，研究方向：记忆性T淋巴细胞的研究，国家自然科学基金委（面上项目），2007年，40万元
32. 疟疾疫苗相关的基础免疫学研究，国家自然科学基金委（国际合作项目），2006年，20万元
33. 新型疟疾疫苗的研制，国家自然科学基金委（面上项目），2003年，19万元
34. 以“COVID-19爆发”为基础构建突发公共卫生事件医疗综合决策智能辅助平台的对策体系研究，中国工程院办公厅，2020年，120万元
35. 上海市临床重点风湿免疫科专科建设项目，上海市卫生和计划生育委员会，2019年，393.6万元
36. 常见风湿性疾病新型诊断试剂及药物的研发平台，上海申康医院发展中心，2012年，50万元
37. 强直性脊柱炎易感基因全基因组关联研究，上海市科学技术委员会，2011年，50万元
38. Stat3基因的遗传变异,TH17淋巴细胞与AS的相关性研究，上海市科学技术委员会，2010年，45万元
39. 风湿免疫性疾病资源保藏库，上海市科学技术委员会，2008年，45万元
40. 风湿病的免疫调控机理及免疫干预机制的系统性研究，上海市科学技术委员会，2007年，100万元
41. 单细胞测序技术解析肠道免疫细胞参与强直性脊柱炎关节炎症的机制研究，上海市科学技术委员会，2020年，20万元
42. 多发免疫性疾病和变态反应性疾病的防治研究，科技部项目子课题协作费，2013年，66万元
43. 风湿免疫病诊疗关键技术临床推广及转化应用研究，卫生部（卫生行业科研专项项目），2012年，17.5万元
44. 系统性红斑狼疮分子分型和个体化诊疗技术，科技部课题，2012年，2.6万元
45. 系统性红斑狼疮的临床诊断、综合治疗的研究子课题：中国汉族人SLE易感基金的研究，“十一.五”科技支撑计划子课题，2009年，45万元
46. 一项通用型CAR-T细胞（BRL-301）治疗复发难治性自身免疫病的安全性和有效性的临床研究，长征医院，2023年，100万元
47. 上海市骨科医学临床研究中心，上海市科学技术委员会，2021年，40万元
48. 强直性脊柱炎和类风湿关节炎致病机理及诊疗策略的关键技术研究，长征医院，2020年，50万元
49. “金字塔人才工程”，长征医院，2019年，500万元
50. 第二军医大学重点学科（风湿免疫）建设，第二军医大学，2015年，750万元
51. 生物制剂益赛普治疗自身免疫性关节炎的临床疗效与安全性再评价，上海市科学技术委员会，2012年，18万元
52. 汉族人群类风湿性关节炎易感基因的研究，上海市科学技术委员会，2008年，40万元
53. 类风湿性关节炎易感基因的国际合作研究，上海市科学技术委员会，2007年，20万元
54. 疟疾疫苗相关的基础免疫学研究，上海市科学技术委员会（浦江人才计划），2006年，30万元
55. 新型疟疾疫苗抗疟感染的免疫机制研究，上海市科学技术委员会，2004年，30万元
56. 疟疾疫苗的研制，军队，2004年，30万元
57. 颗粒样重组相关冠状病毒疫苗的研制，军队，2003年，25万元
58. 重组人抗肿瘤坏死因子-α 治疗活动性强直性脊柱炎疗效和安全的临床研究，第二军医大学，2016年，110万元
59. 评估TNFa抑制剂、IL-17A抑制剂和传统疗法治疗强直性脊柱炎髋关节受累受试者的疗效的观察性研究，长征医院，2021年，20万元
60. 强直性脊柱炎HLA-B27特异性表位肽鉴定及其与肠道菌群的关联研究，上海市卫生和计划生育委员会，2018年，5万元
61. “金字塔人才工程”项目，长征医院，2021年，15万元
62. 基于岗位任职需求以症状为核心的海军规培整合课程的探索与实践，长征医院，2023年，2万元
63. 基于单细胞测序技术研究MYC 在强直性脊柱炎异位骨化中的表观遗传机制，海军军医大学，2023年，5万元
64. 预测炎症性关节炎病人对英夫利西单抗治疗反应的遗传学标记的研究，上海市科学技术委员会，？年，10万元
65. 强直性脊柱炎易感基因ERAP1和HLA-B27的交互作用及致病机制的研究，上海市科学技术委员会，？年，10万元
论文发表（近10年）
1. Wang X, Wu X, Tan B, Zhu L, Zhang Y, Lin L, Xiao Y, Sun A, Wan X, Liu S, Liu Y, Ta N, Zhang H, Song J, Li T, Zhou L, Yin J, Ye L, Lu H, Hong J, Cheng H, Wang P, Li W, Chen J, Zhang J, Luo J, Huang M, Guo L, Pan X, Jin Y, Ye W, Dai L, Zhu J, Sun L, Zheng B, Li D, He Y, Liu M, Wu H, Du B, Xu H. Allogeneic CD19-targeted CAR-T therapy in severe myositis and systemic sclerosis achieved durable remission and reversed extensive fibrotic damages. Cell 2024; doi: 10.1016/j.cell.2024.06.027.
2. Baraliakos X, Deodhar A, van der Heijde D, Magrey M, Maksymowych WP, Tomita T, Xu H, Massow U, Fleurinck C, Ellis AM, Vaux T, Shepherd-Smith J, Marten A, Gensler LS. Bimekizumab treatment in patients with active axial spondyloarthritis: 52-week efficacy and safety from the randomised parallel phase 3 BE MOBILE 1 and BE MOBILE 2 studies. Ann Rheum Dis 2024; 83:199-213.
3. Wang T, Sternes PR, Guo XK, Zhao H, Xu C, Xu H. Autoimmune diseases exhibit shared alterations in the gut microbiota. Rheumatology 2024; 63:856-865.
4. Li M, Tian X, Wang Q, Zhao J, Qian J, Yang C, Huang C, Luo H, Xu H, Gu J, Lin J, Wu L, Zhang M, Yang N, Yang P, Liu S, Wei W, Duan X, Liu Y, Zhang Z, Zhang Z, Zhao Y, Zeng X. Improve quality of patient care for systemic lupus erythematosus in China by enhancing the construction of Centers of Excellence. Rheumatol Immunol Res 2023; 4:162-166
5. Tian X, Li M, Liu S, Leng X, Wang Q, Zhao J, Liu Y, Zhao Y, Zhang Y, Xu H, Gu J, Zeng X. Consensus on targeted drug therapy for spondyloarthritis. Rheumatol Immunol Res 2023; 4:47-59
6. Liu Y, Zhang Z, Kang Z, Zhou XJ, Liu S, Guo S, Jin Q, Li T, Zhou L, Wu X, Wang YN, Lu L, He Y, Li F, Zhang H, Liu Y, Xu H. Interleukin 4-driven reversal of self-reactive B cell anergy contributes to the pathogenesis of systemic lupus erythematosus. Ann Rheum Dis 2023; 82:1444-1454
7. Li JX, Wu X, Lee YH, Xu H. West Meets East in Genetics of Ankylosing Spondylitis. Int J Rheum Dis 2023; 26:2122-2126
8. Guo XK, Wang J, van Hensbergen VP, Liu J, Xu H, Hu X. Interactions between host and intestinal crypt-resided biofilms are controlled by epithelial fucosylation. Cell Rep 2023; 42:112754
9. Wang Y，Gan T，Zhou X，Qu S，Xu L，Hu Y，Liu L，Shi S，Lv JC，Lam T，Matthew P，He K，Celine C B，Xu H，Zhang H. MTMR3 risk alleles enhance Toll Like Receptor 9-induced IgA immunity in IgA nephropathy. Kidney Int 2023；104:562-576
10. Kang Z, Wang J, Meng T, Zhang H, Xu D, Gong H, Chang Z, Li Z, Cui X, Xiao J, Qureshi AI, Zhou W, Liu J, Xu H. Pericytes may facilitate SARS-CoV-2 entry into the nervous system. Journal of Bio-X Research 2023; 6:23-36
11. Tian H, Li T, Wang Y, Lu H, Lin L, Wu X, Xu H. The correlations between C-reactive protein and MRI-detected inflammation in patients with axial spondyloarthritis: a systematic review and meta-analysis. Clin Rheumatol 2023; 42:2397-2407
12. Cai B, Lu H, Ye Q, Xiao Q, Wu X, Xu H. Identification of potent target and its mechanism of action of Tripterygium wilfordii Hook F in the treatment of lupus nephritis. Int J Rheum Dis 2023; 26:1529-1539
13. Li Y, Li B, Wang G, Su J, Qiao Y, Ma C, Wang F, Zhu J, Li J, Zhang H, Liu K, Xu H. Engineered protein and Jakinib nanoplatform with extraordinary rheumatoid arthritis treatment. Nano Res 2023; 16: 11197−11205
14. Wang X, Zhu L, Ying S, Liao X, Zheng J, Liu Z, Gao J, Niu M, Xu X, Zhou Z, Xu H. Increased RNA Editing Sites Revealed as Potential Novel Biomarkers for Diagnosis in Primary Sjögren’s Syndrome. J Autoimmun 2023; 138:103035
15. Zhou XJ, Su T, Xie J, Xie QH, Wang LZ, Hu Y, Chen G, Jia Y, Huang JW, Li G, Liu Y, Yu XJ, Nath SK, Tsoi LC, Patrick MT, Berthier CC, Liu G, Wang SX, Xu H, Chen N, Hao CM, Zhang H, Yang L. Genome-wide Association Study in Acute Tubulointerstitial Nephritis. J Am Soc Nephrol 2023; 34: 895-908
16. Bai W, Yang F, Xu H, Wei W, Li H, Zhang L, Zhao Y, Shi X, Zhang Y, Zeng X, Leng X. A multi-center, prospective, open-label, randomized study to explore efficacy and safety of baricitinib in active primary Sjogren's syndrome patients. Trials 2023; 24:112.
17. Jin Q, Liu Y, Zhang Z, We X, Chen Z, Tian H, Kang Z, Wu X, Xu H. MYC Promotes Fibroblast Osteogenesis by Regulating ALP and BMP2 to Participate in Ectopic Ossification of Ankylosing Spondylitis. Arthritis Res Ther 2023; 25:28
18. Chi X, Huang M, Tu H, Zhang B, Lin X, Xu H, Dong C, Hu X. Innate and adaptive immune abnormalities underlying autoimmune diseases: the genetic connections. Sci China Life Sci 2023; 66:1482-1517.
19. van der Heijde D, Deodhar A, Baraliakos X, Brown MA, Dobashi H, Dougados M, Elewaut D, Ellis AM, Fleurinck C, Gaffney K, Gensler LS, Haroon N, Magrey M, Maksymowych WP, Marten A, Massow U, Oortgiesen M, Poddubnyy D, Rudwaleit M, Shepherd-Smith J, Tomita T, Van den Bosch F, Vaux T, Xu H. Efficacy and Safety of Bimekizumab in Axial Spondyloarthritis: Results of Two Parallel Phase 3 Randomized Controlled Trials. Ann Rheum Dis 2023; 82:515-526
20. Huang M, Xu H. Genetic susceptibility to autoimmunity-current status and challenges. Adv Immunol 2022; 156:25-54
21. Bai X, Hu X, Wang C, Lim MK, Vilela ALM, Ghadimi P, Yao C, Stanley HE, Xu H. Most influential countries in the international medical device trade: Network-based analysis. Physica A 2022; 604:127889
22. Ye L, Li W F, Shao J, Xu Z, Ju J, Xu H. Fighting Omicron epidemic in China: real-world big data from Fangcang Shelter Hospital during the outbreak in Shanghai 2022. J Infection 2022; 85:436-480
23. Ishigaki K, Sakaue S, Terao C, Luo Y, Sonehara K, Yamaguchi K, Amariuta T, Too CL, Laufer VA, Scott IC, Viatte S, Takahashi M, Ohmura K, Murasawa A, Hashimoto M, Ito H, Hammoudeh M, Emadi SA, Masri BK, Halabi H, Badsha H, Uthman IW, Wu X, Lin L, Li T, Plant D, Barton A, Orozco G, Verstappen SMM, Bowes J, MacGregor AJ, Honda S, Koido M, Tomizuka K, Kamatani Y, Tanaka H, Tanaka E, Suzuki A, Maeda Y, Yamamoto K, Miyawaki S, Xie G, Zhang J, Amos CI, Keystone E, Wolbink G, van der Horst-Bruinsma I, Cui J, Liao KP, Carroll RJ, Lee HS, Bang SY, Siminovitch KA, de Vries N, Alfredsson L, Rantapää-Dahlqvist S, Karlson EW, Bae SC, Kimberly RP, Edberg JC, Mariette X, Huizinga T, Dieudé P, Schneider M, Kerick M, Denny JC; BioBank Japan Project; Matsuda K, Matsuo K, Mimori T, Matsuda F, Fujio K, Tanaka Y, Kumanogoh A, Traylor M, Lewis CM, Eyre S, Xu H, Saxena R, Arayssi T, Kochi Y, Ikari K, Harigai M, Gregersen PK, Yamamoto K, Louis Bridges S Jr, Padyukov L, Martin J, Klareskog L, Okada Y, Raychaudhuri S. Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis. Nat Genet 2022; 54:1640-1651
24. Liu Q, Zhu F, Liu X, Lu Y, Yao K, Tian N, Tong L, David AF, Wang X, Han Y, Li Y, Zhu Y, Hu L, Ji Y, Xu N, Li D, Gu X, Liang R, Gan G, Wu L, Zhang P, Xu T, Hu H, Hu Z, Xu H, Ye D, Yang H, Li B, Tong X. Non-oxidative pentose phosphate pathway controls regulatory T cell function by integrating metabolism and epigenetics. Nat Metab 2022; 4:559-574
25. Wu X, Lu H, Xu H. Andersson lesion in ankylosing spondylitis. Rheumatol Immunol Res 2022; 3: 45
26. Wang L, Jiang L, Pan D, Wang Q, Yin Z, Kang Z, Tian H, Geng X, Shao J, Pan W, Yin J, Fang L, Wang Y, Zhang W, Li Z, Zheng J, Hu W, Pan Y, Yu D, Guo S, Lu W, Li Q, Zhou Y, Xu H. Novel approach by natural language processing for COVID-19 knowledge discovery. Biomed J 2022; 45:472-481.
27. Wu X, Geng X, Shang Z, Wang Z, Lu H, Liu W, Xu H. Post-traumatic stress disorder in patients with rheumatic disease during the COVID-19 outbreak: a cross-sectional case-control study in China. BMJ Open 2022; 12:e049749.
28. Wu X, Xu H, Dong C. Beyond interleukin-17-targeted therapy: Complexity of environment-genetics-immunology needs to be addressed. Chinese Med J-Peking 2022; 135:511-512
29. Ye L, Zhou L, Bian J, Zhao J, Li T, Wu X, Xu H. Disease activity guided stepwise tapering but not discontinuation of biologics is a feasible therapeutic strategy for patients with ankylosing spondylitis: real-world evidence. Adv Ther 2022; 39:1393-1402
30. Ou J, Guan X, Wang J, Wang T, Zhang B, Li R, Xu H, Hu X, Guo XK. Epithelial NELF guards intestinal barrier function to ameliorate colitis by maintaining junctional integrity. Mucosal Immunol 2022; 15:279-288
31. Tian X, Wang Q, Li M, Zhao Y, Zhang Z, Huang C, Liu Y, Xu H, Chen Y, Wu L, Su Y, Xiao W, Zhang M, Zhao D, Sun L, Zuo X, Lei J, Li X, Zeng X. 2018 Chinese guidelines for the diagnosis and treatment of rheumatoid arthritis. Rheumatol Immunol Res 2021; 2:1-14
32. Hu SH, Li H, Yu H, Liu Y, Liu C, Zuo X, Lu J, Jiang J, Xi C, Huang B, Xu H, Hu J, Lai J, Huang M, Liu J, Xu D, Guo X, Wu W, Wu X, Jiang L, Li M, Zhang G, Huang J, Wei N, Lv W, Duan J, Qi H, Hu C, Chen J, Zhou W, Xu W, Liu C, Liang H, Du J, Zheng S, Lu Q, Zheng L, Hu X, Chen F, Chen P, Zhu B, Xu L, Ni Z, Fang Y, Yang Z, Shan X, Zheng E, Zhang F, Zhou Q, Rao Y, Swaab D, Yue W, Xu Y. Discovery of new genetic loci for male sexual orientation in Han population. Cell Discov 2021; 7:103
33. Wang T, Guo X K, Xu H. Disentangling the progression of non-alcoholic fatty liver disease in the human gut microbiota. Front Microbiol 2021;12: 728823
34. Wu X, Zhong J, Wang G, Xu H. Factors relating to bone mineral density in young and middle-aged patients with ankylosing spondylitis. Chinese Med J-Peking 2021; 134:2556-2563
35. Lu H, Wang Y, Wang X, Wu X, Zhou L, Sheng R, Tian H, Li T, Xu H. Yisaipu® provide AS patients with an economical therapeutic option while original biologicals are more advantageous in the COVID-19 epidemic situation. Front Pharmacol 2021; 12: 692768
36. Zhou L, Li T, Wu X, Lu H, Lin L, Ye L, Yin J, Zhao J, Wang X, Bian J, Xu H. Assessment of neuropathic pain in ankylosing spondylitis: prevalance and characteristics. Pain Ther 2021; 10:1467-1479
37. Sun Y, Yin M, Ma L, Dai X, Lv L, Chen X, Ye Sh, Li T, Chen J, Zhao D, Kong R, Wei Q, Yang G, Gong S, Yang C, Liu H, Xue Y, Tang J, Feng R, Ai P, Qin L, Liu H, Su X, Huang H, Guan J, Luo D, Dai SM, Zhao F, Zhu ZH, Zhang X, Han J, Wang J, Xiao C, Xu H, Wu X, He D, Mao J, Zhu Z, Xue L, Li B, Lin J, Zou J, Sun X, Ding J, Dong Z, Wang X, Ying J, Jiang L. Epidemiology of takayasu arteritis in shanghai: a hospital-based study and systematic review. Int J Rheum Dis 2021; 24:1247-1256
38. Lu Y, Li Y, Zhou Ha, Lin J, Zheng Z, Xu H, Lin B, Lin M, Liu L. Affordable measures to monitor and alarm nosocomial SARS-CoV-2 infection due to poor ventilation. Indoor Air 2021; 31:1833-1842
39. Zhang Z, Jara CJ, Singh M, Xu H, Goodnow CC, Jackson KJ, Reed JH. Human transitional and IgMlow mature naïve B cells preserve permissive B-cell receptors. Immunol Cell Biol 2021; 99:865-878
40. Wu X, Wang G, Zhang L, Xu H. Genetics of ankylosing spondylitis-focusing on the ethnic difference between east asia and europe. Front Genet 2021; 12:671682
41. Li Z, Wu X, Leo PJ, De Guzman E, Akkoc N, Breban M, Macfarlane GJ, Mahmoudi M, Marzo-Ortega H, Anderson LK, Wheeler L, Chou CT, Harrison AA, Stebbings S, Jones GT, Bang SY, Wang G, Jamshidi A, Farhadi E, Song J, Lin L, Li M, Wei JC, Martin NG, Wright MJ, Lee M, Wang Y, Zhan J, Zhang JS, Wang X, Jin ZB, Weisman MH, Gensler LS, Ward MM, Rahbar MH, Diekman L, Kim TH, Reveille JD, Wordsworth BP, Xu H, Brown MA; TCRI AS Group. Polygenic risk scores have high diagnostic capacity in ankylosing spondylitis. Ann Rheum Dis 2021; 80:1168-1174
42. Deodhar A, Sliwinska-Stanczyk P, Xu H, Baraliakos X, Gensler LS, Fleishaker D, Wang L, Wu J, Menon S, Wang C, Dina O, Fallon L, Kanik KS, van der Heijde D. Tofacitinib for the treatment of ankylosing spondylitis: a phase Ⅲ, randomised, double‑blind, placebo-controlled study. Ann Rheum Dis 2021; 80:1004-1013
43. Bai H, Jiang L, Li T, Liu C, Zuo X, Liu Y, Hu S, Sun L, Zhang M, Lin J, Xiao W, Wang Q, Zhao D, Wu H, Kong X, Gao W, Hou W, Seong M, Zhang Y, Chen F, Chen S, Wu X, Bao C, Wang L, Xu H. Acute effects of air pollution on lupus nephritis in patients with systemic lupus erythematosus: A multicenter panel study in China. Environ Res 2021; 195:110875
44. Zhang X, Xu H, Zhang Z, Li Y, Pauer L, Liao S, Zhang F. Efficacy and safety of pregabalin for fibromyalgia in a population of Chinese subjects. J Pain Res 2021;14:537-548
45. Zhou X, Tsoi L, Hu Y, Patrick M, He K, Berthier C, Li Y, Wang Y, Qi Y, Zhang Y, Gan T, Li Y, Hou P, Liu L, Shi S, Lv J, Xu H, Zhang H. Exome chip analyses and genetic risk for IgA nephropathy among Han Chinese. Clin J Am Soc Nephrol 2021; 16: 213-224
46. Wu X，Zheng H, wang C, Xu S, Gao G, Li M, Wang Z, Jiang C, Dou Z, Xiao Y, Xie K, Wang S, Xu H. A novel privacy-preserving federated genome-wide association study framework and its application in identifying potential risk variants in ankylosing spondylitis. Brief Bioinform 2021; 22: bbaa090
47. Li M, Zhao Y, Zhang Z, Huang C, Liu Y, Gu J, Zhang X, Xu H, Li X, Wu L, Song Y, Li X, Jin H, Lei J, Chen Y, Zeng X, Chinese Rheumatology Association, National Clinical Research Center for Dermatologic and Immunologic Diseases, Chinese Systemic Lupus Erythematosus Treatment and Research Group. 2020 Chinese guidelines for the diagnosis and treatment of systemic lupus erythematosus. Rheumatol Immunol Res 2020; 1: 5-23
48. Brown MA, Xu H, Li Z. Genetics and the axial spondyloarthritis spectrum. Rheumatology 2020; 59: iv58-iv66
49. Wang L, Wang Q, Bai H, Liu C, Liu W, Zhang Y, Jiang L, Xu H, Wang K, Zhou Y. EHR2Vec: representation learning of medical concepts from temporal patterns of clinical notes based on self-attention mechanism. Front Genet 2020; 11: 630
50. Li B, Lu C, Oveissi S, Song J, Xiao K, Zanker D, Duan M, Chen J, Xu H, Zou Q, Wu C, Yewdell JW, Chen W. Host CD8α+ and CD103+ dendritic cells prime transplant antigen-specific CD8+ T cells via cross-dressing. Immunol Cell Biol 2020; 98: 563-576
51. Zhang H, Kang Z, Gong H, Xu D, Wang J, Li Z, Li Z, Cui X, Xiao J, Zhan J, Meng T, Zhou W, Liu J, Xu H. Digestive system is a potential route of COVID-19: an analysis of single-cell coexpression pattern of key proteins in viral entry process. Gut 2020; 69:1010-1018
52. Wang G, Kim TH, Li Z, Cortes A, Kim K, Bang SY, Leo P, Brown MA, Xu H. MHC associations of ankylosing spondylitis in East Asians are complex and involve non-HLA-B27 HLA contributions. Arthritis Res Ther 2020; 22:74
53. Shi XY, Wang G, Li T, Li Z, Leo P, Liu Z, Wu G, Zhu H, Zhang Y, Li D, Gao L, Yang L, Wang W, Liao J, Wang J, Zhou S, Wang H, Li X, Gao J, Zhang L, Shu X, Li D, Li Y, Chen C, Zhang X, Partida GC, Lundberg M, Reutens D, Bartlett P, Brown MA, Zou LP, Xu H. Identification of susceptibility variants to benign childhood epilepsy with centro-temporal spikes (BECTS) in Chinese Han population. EBioMedicine 2020; 57:102840
54. Liu Y, Wu X, Ye L, Xu H. Successful treatment of a patient with Kasabach-Merritt syndrome and multiple giant hepatic hemangiomas. J Int Med Res 2020; 48: 300060519898358
55. Li T, Liu Y, Sheng R, Yin J, Wu X, Xu H. Correlation between chronic pain acceptance and clinical variables in ankylosing spondylitis and its prediction role for biologics treatment. Front Med 2020; 7:17
56. Yin J, Sternes PR, Wang M, Song J, Morrison M, Li T, Zhou L, Wu X, He F, Zhu J, Brown MA, Xu H. Shotgun metagenomics reveals an enrichment of potentially cross-reactive bacterial epitopes in ankylosing spondylitis patients, as well as the effects of TNFi therapy upon microbiome composition. Ann Rheum Dis 2020; 79:132-140
57. Xu H, Yin J. HLA risk alleles and gut microbiome in ankylosing spondylitis and rheumatoid arthritis. Best Pract Res CL RH 2019; 33:101499
58. Jiang N, Li M, Zhang M, Xu J, Jiang L, Gong L, Wu F, Gu J, Zhao J, Xiang Y, Wang Z, Zhao Y, Zeng X, and CSTAR co-authors. Chinese SLE treatment and research group (CSTAR) registry: clinical significance of thrombocytopenia in Chinese patients with systemic lupus erythematosus. Plos One 2019; 14: e0225516
59. Zhang W, Zhang H, Liu S, Xia F, Kang Z, Zhang Y, Liu Y, Xiao H, Chen L, Huang C, Shen N, Xu H, Li F. Excessive CD11c(+)T bet(+) B cells promote aberrant T-FH differentiation and affinity-based germinal center selection in lupus. P Natl Acad Sci USA 2019; 116: 18550-18560
60. Wu X, Lu H, Xu H. Andersson lesion in ankylosing spondylitis misdiagnosed as spinal tuberculosis: two cases. Int J Clin Exp Med 2019; 12:14001-14004
61. Li T, Zhou L, Zhao H, Song J, Wang X, Liu S and Xu H. Fatigue in ankylosing spondylitis is associated with psychological factors and brain gray matter. Front Med 2019; 6:271
62. Xu H, Li Z, Wu J, Xing Q, Shi G, Li J, Liu X, Wu L, Li X, Tan W, He D, Bi L, Li H, Xiao Z, Shuai Z, Li X, Wang Y, Luo L, Zheng Y, Xiao W, Wu X, Zhou L, Li T, Qian L, Zhou H, Lu S, Zheng S, Xiong Y, Wang X, Wang Y, Wu X. IBI303, a biosimilar to adalimumab, for the treatment of patients with ankylosing spondylitis in China: a randomised, double-blind, phase 3 equivalence trial. Lancet Rheumatology 2019; 1: e35–43
63. Liu Y, Zhang Z, Jin Q, Liu Y, Kang Z, Huo Y, He Z, Feng X, Yin J, Wu X, Wang H, Xu H. Hyperprolactinemia is associated with a high prevalence of serum autoantibodies, high levels of inflammatory cytokines and an abnormal distribution of peripheral B-cell subsets. Endocrine 2019; 64:648-656
64. Khanniche A, Zhou L, Jiang B, Song J, Jin Y, Yin J, Wang S, Ji P, Shen H, Wang Y and Xu H. Restored and enhanced memory T cell immunity in rheumatoid arthritis after TNFα blocker treatment. Front Immunol 2019; 10:887
65. Wu X, Sheng X, Sheng R, Lu H, Xu H. Genetic and clinical markers for predicting treatment responsiveness in rheumatoid arthritis. Front Med-Prc 2019; 13:411-419
66. Bi L, Li Y, He L, Xu H, Jiang Z, Wang Y, Li X, Wei W, Gu J, Wang G, Zhang Z, Zhou B, Liu Y, Wu Z, Liu H, He D, Lv Z, Li Z, Zuo X, Dong L, Wu H, Zhang H, Chen H, Bao C, Zhang Z, Zhang M, Song H, Zheng Y, Jiang L, Liu X, Boehnlein M, Dunkel J, Shao J, Harris K, Li Z. Efficacy and safety of certolizumab pegol in combination with methotrexate in methotrexate-inadequate responder Chinese patients with active rheumatoid arthritis: 24-week results from a randomised, double-blind, placebo-controlled phase 3 study. Clin Exp Rheumatol 2019; 37:227-234
67. Zhang T, Zhang J, Liu X, Zhang L, Zhao D, Wu X, Xu H. A clinical analysis of prognostic factors for dermatomyositis-associated interstitial lung disease. Int J Clin Exp Med 2018; 11: 5903-5911
68. Qi Y, Zhou X, Nath SK, Sun C, Wang Y, Hou P, Mu R, Li C, Guo J, Li Z, Wang G, Xu H, Hao Y, Zhang Z, Yue W, Zhang H, Zhao M, Zhang H. A rare variant (rs933717) at FBXO31-MAP1LC3B in Chinese is associated with systemic lupus erythematosus. Arthritis Rheumatol 2018; 70:287-297
69. Li Z, Liu Y, Xu H, Chen Z, Bao C, Gu J, Zhao D, An Y, Hwang L, L Wang, Kremer J, Wu Q. Efficacy and safety of tofacitinib in Chinese patients with rheumatoid arthritis. Chinese Med J-Peking 2018; 131:2683-2692
70. Zhang X, Zuo Y, Li C, Tu X, Xu H, Guo J, Li Z, Mu R. IL1F7 gene polymorphism is not associated with rheumatoid arthritis susceptibility in the northern Chinese Han population: a case-control study. Chinese Med J-Peking 2018; 131:171-179
71. Chen Y, Ouyang J, Yang R, Maarouf MH, Wang X, Chen B, Liu S, Hu J, Guo G, Zhang J, Dai SM, Xu H, Chen J. Silencing SOCS3 markedly deteriorates spondyloarthritis in mice induced by minicircle DNA expressing IL23. Front Immunol 2018; 9:2641
72. Luo D, Shen Y, Lyu J, Fan Y, Huang D, Lin W, Shen H, Xu H, Guan J. Effect of Mechanical Stress in Combination with Verapamil on Levels of Aggrecan and ADAMTS-5 mRNAs and Proteins in Human Osteoarthritic Chondrocyte/Agarose Constructs. Chinese Med J-Peking 2018; 131:2229-2231
73. Benyamin B, He J, Zhao Q, Gratten J, Garton F, Leo PJ, Liu Z, Mangelsdorf M, Al-Chalabi A, Anderson L, Butler TJ, Chen L, Chen XD, Cremin K, Deng HW, Devine M, Edson J, Fifita JA, Furlong S, Han YY, Harris J, Henders AK, Jeffree RL, Jin ZB, Li Z, Li T, Li M, Lin Y, Liu X, Marshall M, McCann EP, Mowry BJ, Ngo ST, Pamphlett R, Ran S, Reutens DC, Rowe DB, Sachdev P, Shah S, Song S, Tan LJ, Tang L, van den Berg LH, van Rheenen W, Veldink JH, Wallace RH, Wheeler L, Williams KL, Wu J, Wu X, Yang J, Yue W, Zhang ZH, Zhang D, Noakes PG, Blair IP, Henderson RD, McCombe PA, Visscher PM, Xu H, Bartlett PF, Brown MA, Wray NR, Fan D. Cross-ethnic meta-analysis identifies association of the GPX3-TNIP1 locus with amyotrophic lateral sclerosis. Nat Commun 2017; 8:611
74. Zhou L, Wang G, Liu X, Song J, Chen L, Xu H. Matrix metalloproteinase-3 and the 7-joint ultrasound score in the assessment of disease activity and therapeutic efficacy in patients with moderate to severe rheumatoid arthritis. Arthritis Res Ther 2017; 19:250
75. Yu H, Yan H, Li J, Li Z, Zhang X, Ma Y, Mei L, Liu C, Cai L, Wang Q, Zhang F, Iwata N, Ikeda M, Wang L, Lu T; Chinese Schizophrenia Collaboration Group; Li M, Xu H, Wu X, Liu B, Yang J, Li K, Lv L, Ma X, Wang C, Li L, Yang F, Jiang T, Shi Y, Li T, Zhang D, Yue W. Common variants on 2p16.1, 6p22.1 and 10q24.32 are associated with schizophrenia in Han Chinese population. Mol Psychiatry 2017; 22:954-960
76. Zhang T, Liu X, Xu H. Dermatomyositis with renal infarction: a case report and literature review. J Int Med Res 2017; 45: 2153-2157
77. Gratten J, Zhao Q, Benyamin B, Garton F, He J, Leo PJ, Mangelsdorf M, Anderson L, Zhang ZH, Chen L, Chen XD, Cremin K, Deng HW, Edson J, Han YY, Harris J, Henders AK, Jin ZB, Li Z, Lin Y, Liu X, Marshall M, Mowry BJ, Ran S, Reutens DC, Song S, Tan LJ, Tang L, Wallace RH, Wheeler L, Wu J, Yang J, Xu H, Visscher PM, Bartlett PF, Brown MA, Wray NR, Fan D. Whole-exome sequencing in amyotrophic lateral sclerosis suggests NEK1 is a risk gene in Chinese. Genome Med 2017; 9: 97
78. Yin J, He D, Jiang L, Cheng F, Guo Q, Huang S, Zeng X, Liu Y, Brown MA, Xu H. Influence of cigarette smoking on rheumatoid arthritis risk in the Han Chinese population. Front Med 2017; 4:76
79. Li T, Liu Y, Xu H. Successful treatment of infliximab in a patient with scleroderma: a case report. Medicine 2017; 96: e6737
80. Qian F, Li M, Chen Y, Jiang L, Xu H. Salmonella flagellin acted as an effective fusion partner for expression of plasmodium falciparum surface protein 25 in escherichia coli. Hum Vacc Immunother 2016; 12:2362-2364
81. Okada Y, Suzuki A, Ikari K, Terao C, Kochi Y, Ohmura K, Higasa K, Akiyama M, Ashikawa K, Kanai M, Hirata J, Suita N, Teo YY, Xu H, Bae SC, Takahashi A, Momozawa Y, Matsuda K, Momohara S, Taniguchi A, Yamada R, Mimori T, Kubo M, Brown MA, Raychaudhuri S, Matsuda F, Yamanaka H, Kamatani Y, Yamamoto K. Contribution of a non-classical HLA gene, HLA-DOA, to the risk of rheumatoid arthritis. Am J Hum Genet 2016; 99:366-374
82. Ye L, Goodall JC, Zhang L, Putintseva EV, Lam B, Jiang L, Liu W, Yin J, Lin L, Li T, Wu X, Yeo G, Shugay M, Chudakov DM, Gaston H, Xu H. TCR usage, gene expression and function of two distinct FOXP3(+) treg subsets within CD4(+) CD25(hi) T cells identified by expression of CD39 and CD45RO. Immunol Cell Biol 2016; 94:293-305
83. Qian F, Yin J, Li M, Guo A, Li T, Zhou L, Wu X, Xu H. Intranasal immunization with a peptide conjugated to salmonella flagellin induces both systemic and mucosal peptide-specific antibody responses in mice. Microbiol Immunol 2016; 60:497-500
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